To understand the human genome, scientists focused on protein-coding genes and their functions for decades. This has given us ...

A team from University of Toronto Engineering is the first to synthesize long noncoding RNA (lncRNA) outside the cell—a new approach to drug discovery that has already yielded some promising ...

The function of non-coding RNA in the cell has long been a mystery to researchers. Unlike coding RNA, non-coding RNA does not produce proteins—yet it exists in large quantities. A research team from ...

Retinitis pigmentosa (RP) is a genetic eye disorder affecting around one in 5,000 people worldwide. It typically begins with night blindness in youth and progresses to tunnel vision as ...

Terc-53 functions as a molecular scaffold bringing together Hmmr and Trim25, accelerating Hmmr’s ubiquitination-mediated degradation, which consequently leads to neuroinflammation and cognition ...

Explore the breakthrough of lab-made lncRNA by University of Toronto Engineering for new drug discovery potential.

Biology textbooks explain that cells follow a universal rule when processing gene transcripts to make proteins. Non-coding ...

When a gene produces too much protein, it can have devastating consequences on brain development and function. Patients with an overproduction of protein from the chromodomain helicase DNA binding ...

Although there are striking differences between the cells that make up your eyes, kidneys, brain and toes, the DNA blueprint for these cells is essentially the same. Where do those differences come ...